Updated: 23 July 2016
Do you know what government politicians and transfusion medicine TM) leaders have in common? No matter what the threat, both repeatedly assure their constituencies, 'Don't worry, be happy.'
July's blog takes its theme from recent transfusion-transmissible disease news. The title is from a 1988 ditty by Bobby McFerrin.
The blog's aim is to encourage readers to be skeptical about how safe our blood supply is and to hold our TM leaders to the highest standard, one higher than we expect from politicians.
Examples of politicians assuring citizens all is okay:
- Canada: PM Justin Trudeau reassures Canadians that economy is in a good position to weather the storm in the wake of Britain's Brexit vote. (June 2016)
- UK: Home Secretary Theresa May assures Brits that the UK has taken steps to amend powers and increase capabilities to deal with developing terrorist threats. (Aug. 2014)
- USA: Obama assures Americans the highest priority is their safety following a string of terror attacks (Dec. 2015)
Similarly, all involved at top echelons of the blood industry in the developed world constantly reassure us that our blood supply is the safest it ever has been.
Unstated is the blood supply is the safest it has ever been for the KNOWN OLD infectious disease risks, the ones that figured in the so-called 'tainted blood' scandals that plagued us in past decades. Experts assure us
- *We are doing all we can to minimize risks.
- Donor screening, improved transmissible disease (TD) tests, and manufacturing processes for plasma-derived products pretty much eliminate the old TD risks like hepatitis B, hepatitis C, HIV.
- The blood supply is safe. Don't worry, be happy.
- Today western nations have pretty much all moved from a total ban on blood donation for MSM males to a 5 year deferral to a one-year deferral, providing no MSM in the past year.
- Blood suppliers did so influenced by nation-wide, indeed global, campaigns by gay activists and others who support their cause. They decried the ban against gay/bisexual men donating blood, including the latest one-year deferral, calling it discriminatory and unjustified based on the evidence.
- Some even say the ban on MSM was unjustified from the get-go:
- 'The new policy isn't any more scientific than the old policy. It's based on the same bigotry and gay panic defence that the ban has been based on since the beginning.'
Examples of news that triggered this blog:
- CDC Press Release (July 20, 2016) : Gay and bisexual teen males no more likely than heterosexual teen males to engage in sexual risk behaviors but at substantially higher risk of HIV infection:
- HIV diagnosis rates are 57 times higher among men who have sex with men (MSM) than among heterosexual men.
Several disconcerting anomalies exist about Zika virus transmission:
- What the hell is going on? (Well worth a read)
TM leaders standard response (SOP?) to blood supply risks is analogous to politicians who ensure citizens that 'all is okay'. And TM leaders are more-or-less correct, just as politicians are about their claims of relative public safety from economic disasters and terrorism. Except when the next man-made disaster strikes, as it inevitably does.
For both groups, claiming safety makes sense and often is in the public interest. The last thing citizens need is to fear for their safety, fear to travel, fear that those who are different ('the other') are somehow dangerous. Politicians who fear-monger usually do so in their own self-interest and often are despicable in spinning tragedies to their crass political benefit.
TM leaders never-ever fear monger. It's not in their best interest or ours, whether as blood donors or transfusion recipients. For the best of reasons TM leaders correctly assure us that life-saving transfusions are the safest they have ever been. Such reassurances serve the public interest because we don't want folks to fear life-saving transfusions or stop donating blood.
Yet many in the TM community come across as complacent and overly confident. I'd love to be similar, live in a bubble, sing 'Don't worry, be happy.' But, having experienced Canada's 'tainted blood' scandals, I'm skeptical. Note, skeptical, not cynical.
Partly it's because TM leaders failed us in the HIV tragedy. Out of arrogance or being true-believers matters not:
- And the Band Played On (full movie on Youtube - it's a beauty)
- Canadian Red Cross denies link between AIDS and blood products
- Two-minute video
- In the 1980s a Canadian Red Cross (CRC) medical director uses 'cost-benefit ratio" to determine if hemophiliacs should be transfused with potentially infected products
- Reality: FVIII concentrates from thousands of donors were all infected with HIV, including untreated FVIII conc., probably transfused to use up CRC's expensive stock pile.
- Note: Over 1100 Canadians were infected with HIV from blood transfusions, of which 700 had hemophilia and were treated with FVIII concentrates.
- The tragic history of AIDS in the hemophilia population 1982-1984
- Closing the circle: a thirty-year retrospective on the AIDS/blood epidemic
CBS and others now use data - based on prevalence and disease severity - that determine whether a blood supplier implements a blood safety test or not for a given transfusion-transmissible risk. Today's blood suppliers are all about metrics and cost-savings, and they're proud of it, even crow about it.
Just like the Canadian Red Cross was when it declined to implement surrogate tests for hepatitis non-A, non-B (now hepatitis C). Seems Canada's experts judged surrogate tests to lack sufficient sensitivity and specificity. That tens of 1000s of Canadian transfusion recipients were subsequently infected with HCV is a testament to 'expert' opinion. It ain't infallible, especially if driven by cost constraints.
Yes, I've written variations on this theme before. But I hope readers see how true the analogy of TM leaders being the same as political leaders who constantly reassure us (as a knee-jerk reaction) that we're safe because they're doing all they can to combat the risks we face.
I don't want folks to become fearful of our blood supply. It's safer than ever, although not bulletproof. Rather I encourage readers to be skeptical, i.e., to have some degree of doubt regarding claims that are normally taken for granted just because they come from our leaders.
In this case to be skeptical about what our TM 'thought leaders' tell us about blood safety, especially given the ever-evolving transfusion-transmissible threats AND the fact that commercial vested interests (Big Pharma, the diagnostic test industry) are now - more so than ever - in bed with transfusion professionals.
SIDE BAR (Food for Thought)
Let's consider the small picture of vested interests. Many experts who present at company-funded continuing education events or any CE event have strong ties to industry.
Think about the issue on a personal scale. Have you ever attended a TM talk, workshop, seminar sponsored by Big Pharma or a diagnostic test firm? If yes, have you even once heard representatives discuss anything that casts any doubt whatsoever on their products and its benefits? Suspect not.
When attending CE events do you assess what ties the speakers have to industry? Or mostly listen in awe to the acknowledged world-renowned experts who transitioned from their original health care careers and now more or less work for profit-driven private industry?
Let's say I've built a good career on specializing in DNA genotyping of red cell antigens. What are the odds I'd be for each and every use of molecular typing in TM and a strong proponent of so-called personalized medicine?
Suppose one of my roles is as an academic whose career and advancement depend on getting my research funded and published? How likely would I be to criticize industry partners who fund my research? Or try to publish negative studies that don't support the company's products?Now let's return to the big picture. I'm not suggesting TM leaders are consciously influenced by commercial interests - who often just happen to be their industry partners (although they clearly are influenced in many ways) - on matters of blood safety. Rather my point is that people invariably act in their own best interests. Human nature...
Those in charge of the safety of our blood supply cannot admit the supply is unsafe. Just as politicians responsible for public safety cannot say citizens are unsafe. It's impossible. This means that you and I must be skeptical and not meekly accept pronouncements from on high about anything, including decisions influenced by pressure groups.
The blog's theme perfectly fits this 1988 Bobby McFerrin song:
- Don't worry, be happy (Bobby McFerrin)