The NCBI (includes PubMed) has a toolbar (in beta testing) for use with either Internet Explorer or Mozilla Firefox.
If you use Google's toolbar, the NCBI toolbar is similar. Instead of choosing to search the web, news, images, etc., (as in Google), the NCBI toobar allows you to select from several databases (PubMed, gene, nucleotide, all). As in Google, you can also highlight your search terms.
Read more and download here:
www.ncbi.nlm.nih.gov/projects/toolbar/
Cheers, Pat
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